abstract：:The antioxidant 2-mercaptoethylamine (MEA) was added to the culture medium of WI-38 cells throughout their lifespan. MEA concentrations of 0.5 microM, 5 microM and 50 microM were used. The presence of 5 microM or 50 microM MEA decreased the fraction of rapidly dividing cells and slightly reduced cell density at conflu...

journal_title：Experimental gerontology

authors： Golczewski JA

更新日期：1984-01-01 00:00:00

abstract：:Ascorbic acid decreases from age-group I to II in Kidney, skeletal muscle, and increases in the Pancreas of female. There is no significant change in the Pancreas of male toad. There is an increase in the ascorbic acid content from age group II to III except in the Pancreas of females, where there is a decline of the ...

journal_title：Experimental gerontology

authors： Panda AK,Ruth RP,Padhi SN

更新日期：1984-01-01 00:00:00

abstract：:Histological surveys of the hearts of guppies Poecilia reticulatus throughout their lifespan showed no aging changes until the fish were three years old. In younger fishes the hearts were healthy, even in three individuals with "wasting" disease, where there was considerable loss of muscle throughout the body. There w...

journal_title：Experimental gerontology

authors： Woodhead AD

更新日期：1984-01-01 00:00:00

abstract：:Concanavalin-A (Con-A) reactivity was studied to identify the tissue-specificity of cells established from various normal human tissues. Cells were treated with Con-A-labelled human red blood cells (C-RBC). C-RBC was not absorbed on the cells derived from the bone marrow, skin and liver. Lung-derived fibroblast cells ...

journal_title：Experimental gerontology

authors： Ban S,Iida S

更新日期：1983-01-01 00:00:00

abstract：:Motor performance of rats of different ages was determined in a cross sectional study. The design includes a test battery of seven motor tasks of graduated complexity. The results show a hierarchical order of impairments of motor functions in aging rats; that is, the more complex the task requirement, the earlier and ...

journal_title：Experimental gerontology

authors： Jänicke B,Schulze G,Coper H

更新日期：1983-01-01 00:00:00

abstract：:Initial velocity of GABA uptake in hypothalamic synaptosomes has been measured in aged animals as a function of both sodium and GABA concentration and compared to previous studies in young animals. The data give good fit to the model found previously to give minimal best fit to control data. Thus it appears that aging...

journal_title：Experimental gerontology

authors： Wheeler DD

更新日期：1983-01-01 00:00:00

abstract：:Alterations in heparan sulfate, the principal glycosaminoglycan species in glomerular basement membrane, have been proposed as contributory to permeability changes in nephropathic disorders. In the present study, the extent of sulfation of glycosaminoglycans isolated from pronase digests of human glomerular basement m...

journal_title：Experimental gerontology

authors： Cohen MP,Ku L

更新日期：1983-01-01 00:00:00

abstract：:To test if the adrenocortical axis of the rat loses sensitivity to negative feedback control during aging, we examined corticosterone secretion under basal, stressed and post-stress conditions in young and in aged Fisher male rats. We find no age-related change in the speed or magnitude of the stress response or in th...

journal_title：Experimental gerontology

authors： Sapolsky RM,Krey LC,McEwen BS

更新日期：1983-01-01 00:00:00

abstract：:Ethanol ingestion has been implicated in accidental hypothermia of the elderly, but there is no prior data on the relative sensitivity to alcohol of aged homeotherms that might account for disproportionate dysthermia in this age group. To assess their sensitivity, ethanol (0.5-2.0 g/kg) or H20 was given by gavage to s...

journal_title：Experimental gerontology

authors： Murphy MT,Lipton JM

更新日期：1983-01-01 00:00:00

abstract：:This study investigated the effect (in vivo) of centrophenoxine (Helfergin) on the activity of antioxidant enzymes (glutathione peroxidase GSH-PER, glutathione reductase GSSG-RED, superoxide dismutase SOD and catalase) in subcellular fractions from the regions of the brain (cerebrum, cerebellum and brain stem) of rats...

journal_title：Experimental gerontology

authors： Roy D,Pathak DN,Singh R

更新日期：1983-01-01 00:00:00

abstract：:Thiazolidine carboxylic acid (TCA) is a natural liver metabolite whose Mg-salt increased lifespan of flies and mice (Miquel and Economos, 1979, Exp. Geront. 14: 279). We studied the physiological and cellular fine structural effects of various concentrations of TCA in the food of male Drosophila. Flies on 0.3% TCA at ...

journal_title：Experimental gerontology

authors： Economos AC,Ballard RC,Miquel J,Binnard R,Philpott DE

更新日期：1982-01-01 00:00:00

abstract：:Histopathological and autofluorescence investigations were carried out to study lipofuscin pigment accumulation in various age groups of mice. Qualitative studies revealed an increase of lipofuscin pigment accumulation in old animals. Quantitative studies showed a significant increase in the percentage of pigmented ne...

journal_title：Experimental gerontology

authors： Goyal VK

更新日期：1982-01-01 00:00:00

abstract：:The intrinsic contractile properties of papillary muscles isolated from female Wistar rats during post-natal development were examined. In addition, the myocardial responsiveness to certain inotropic interventions was studied. In muscles from 60-day-old animals, the velocity of shortening was markedly greater than mus...

journal_title：Experimental gerontology

authors： Capasso JM,Sonnenblick EH

更新日期：1982-01-01 00:00:00

abstract：:Mitochondria isolated from the livers of old rats (26-30 months) were found to incorporate 41% less leucine into mitochondrial proteins as compared to those from young rats (2-3 months). The initial rates of incorporation of label were 145 cpm/mg/min for the "old" animals, and 320 cpm/mg/min for the young animal. No d...

journal_title：Experimental gerontology

authors： Marcus DL,Lew G,Gruenspecht-Faham N,Freedman ML

更新日期：1982-01-01 00:00:00

abstract：:Plasma and pituitary concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (Prl) were determined by radioimmunoassay in young (2-4 months-old) and aged CD-1 (14-18 months-old) and C57BL/6 (16-22 months-old) mice one month after ovariectomy. In young, ovariectomized mice, plasma ...

journal_title：Experimental gerontology

authors： Parkening TA,Collins TJ,Smith ER

更新日期：1982-01-01 00:00:00